Combination drug therapies
There has been long experience with combinations of different drugs used for intracavernosal injection, although they are unapproved and there is limited evidence for their efficacy and safety. ‘Trimix’ (papverine 30 mg/ml, phentolamine I mg/ml, alprostadil 10 fxg/ml) and ‘bimix’ (papverine 30 mg/mJ, phentolamine I mg/ml) are widely used at varying doses in urological practice in the United States, although less so in Europe. Bimix is offered where the alprostadil component of Trimix causes bothersome penile pain. These combinations have been reported as effective when alprostadil has failed as a single agent. Papaverine was first reported as an effective pharmacotherapy for ED in 1982; with the addition of phentolamine, Bimix has been used since 1983, with Trimix being used rather more recently.
Tags: Combination Drug Therapies, Combinations, Drugs, Efficacy, Europe, Fxg, Ml, Papaverine, Penile Pain, Pharmacotherapy, Trimix